I got a copy of Deadlands: Ghost Towns in the mail last week. In the back it has a random town generator that uses a deck of cards. Let's see how it goes:
Basic info: 8 of hearts = Medium town, a settlement created to make a profit.
Population's outlook: King of spades = Overly, creepily friendly populace at war internally with a powerful figure.
The Weird: Ace of hearts = Someone accidentally unleashed unspeakable evil; the town is accursed now.
Extra color: A mad scientist seeks funding for her research. A casino with a secret room that allows you to hear anything said in the gambling parlor.
Distinguishing mark: someone in the town is famous.
Plot hook: Investigation--players have to piece together what is going on in the town.
Okay, let's put this all together: Vulture's Chapel is a small frontier town that grew up around a trading post where Indians and settlers did commerce. All was well until Quick Thomas Cardew (a famous gunfighter) arrived, looking to buy land from the Indians. When they wouldn't agree to his terms, he decided that a show of arms might convince them; he was cursed by the tribe's shaman and has subsequently brought that curse back to the town of Vulture's Chapel.
Part of the curse is that everyone afflicted by it must benice in the extreme. (It's a reversal of Cardew's antagonistic attitude toward the native population.) The people suspect that the curse that afflicts them is Thomas's fault, but they can't do anything against him--or even speak out about their suspicions--because of the nature of the curse and the way it forcibly alters their demeanor.
Loretta McNeil, a mad scientist who has recently set up shop in town, is a red herring; while the weirdness in town might be attributed to her tampering with weird science, she's just an eccentric inventor. The players will have to use some shrewd investigation to figure out what's what since the townspeople can't speak their minds.
Yep, this has potential.